Clinical trial participants who maintained protein intake above 90g daily during Retatrutide treatment showed significantly better lean mass retention than those who let protein intake decline with overall appetite
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It does not significantly impact natural testosterone production at moderate doses, making recovery easier
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Its concurrent engagement of GLP-1R, GIPR, and GCGR distinguishes it structurally and pharmacologically from both selective GLP-1R agonists such as semaglutide and dual GLP-1R/GIPR agonists such as tirzepatide
Current evidence supports safe use for at least four years based on the SELECT trial